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- S. B. Gaikwad
- A. V. Chandewar
- A. B. Roge
- R. S. Sakhare
- S. G. Shep
- Piyush K. Rekhawar
- A. V. Chendewar
- Santhosh Shep
- Keshao Giradkar
- B. Roge Ashish
- S. Sakhare Ram
- M. A. Channawar
- B. V. Bakde
- S. R. Gawande
- M. N. Dahake
- P. P. Wattamwar
- R. A. Bongirwar
- D. S. Mohale
- N. I. Kochar
- A. P. Devani
- A. D. Dewani
- M. D. Kshirsagar
- Jagdish V. Manwar
- Bhagwat U. Nagargoje
- Vishal C. Gurumukhi
- Dipti G. Ratnaparkhi
- Poonam P. Warade
- Dipak D. Kumbhar
- Rahul S. Manmode
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Bakal, R. L.
- Ursodeoxycholic Acid as a Biliary Agent Used in the Treatment of Liver Disease: An Overview
Abstract Views :215 |
PDF Views:1
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal - 445001, IN
1 P. Wadhwani College of Pharmacy, Yavatmal - 445001, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 6 (2010), Pagination: 355-362Abstract
Ursodeoxycholic acid is a dihydroxy bile acid with a rapidly expanding spectrum of usage in acute and chronic liver diseases. The various mechanisms of action of this hydrophilic bile acid include direct cytoprotection, detergent action on dysfunctional microtubules, immunomodulation and induction of hypercholeresis.Its efficacy in primary biliary cirrhosis and primary sclerosing cholangitis as an adjunct to medical therapy has been well established. Newer indications include its use in the management of chronic hepatitis, cirrhosis, post liver transplant rejection, graft versus-host disease and acute viral hepatitis, where it not only relieves symptoms of holestasis but also arrests ongoing hepatocyte necrosis.
Keywords
Biliary Cirrhosis, Primary Sclerosing Cholangitis, Ursodeoxycholic Acid.References
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- Novel Method of Transdermal Drug Delivery: Iontophoresis
Abstract Views :204 |
PDF Views:0
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal (MS), IN
1 P. Wadhwani College of Pharmacy, Yavatmal (MS), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 3 (2010), Pagination: 215-219Abstract
The highly lipophilic nature of the skin restricts the permeation of hydrophilic, high molecular weight and charged compounds through the stratum corneum into the systemic circulation. However, many therapeutically active drug molecules are hydrophilic and possess high molecular weights for example, peptides. Iontophoresis is an alternative drug and cosmetic delivery system. A low-level electrical current is applied to a similarly charged drug or cosmetic solution. Iontophoresis repels the drug ions which diffuse through the skin to the underlying tissue. In contrast to passive transdermal patch drug delivery, iontophoresis is an active (electrically driven) method that allows the delivery of water-soluble ionic drugs that would not be effectively absorbed through the skin without application of a voltage. This presentation provides a general overview on iontophoresis with the emphasis on possible advantages associated with this system, principles, mechanisms associated with them, summarization of different application and factors affecting iontophoresis, evaluation parameter used to determine the feasibility of using iontophoretic delivery devices to facilitate the transdermal transport of hydrophilic charged macromolecules of peptides, such as vasopressin, and proteins, such as insulin, across the skin.Keywords
Transdermal, Iontophoresis.- Ethosomes:Novel Approach in Transdermal Drug Delivery System
Abstract Views :223 |
PDF Views:0
Authors
B. Roge Ashish
1,
S. Sakhare Ram
1,
R. L. Bakal
1,
M. A. Channawar
1,
B. V. Bakde
1,
S. R. Gawande
1,
A. V. Chandewar
1
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal, IN
1 P. Wadhwani College of Pharmacy, Yavatmal, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 23-27Abstract
Transdermal drug delivery system is emerging system as compaired to oral and parentral.in TDDS, patch system was developed to control the release of drug. Conventional transdermal drug delivery system achieved advantages over the oral and parenteral. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes were been developed as novel transdermal drug delivery system. Firstly, it delivers the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it channel the active entity to the site of action. However, TDDS has limited market success due to the barrier properties of the Stratum Corneum and stability of formulation. ethosomes is better achievement in vesicular drug delivery system, helpful to achieve goal needed by NTDDS. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. This review focus on introduction, mechanism of penetration, method of preparation, methods of characterization and application in the field.Keywords
TDDS, CTDDS, NTDDS, Stratum Corneum , Vesicular Drug Delivery System, Ethosomes.- A Brief Review on Gastro Retentive System
Abstract Views :333 |
PDF Views:0
Authors
M. N. Dahake
1,
P. P. Wattamwar
2,
R. A. Bongirwar
2,
D. S. Mohale
2,
R. L. Bakal
2,
A. V. Chandewar
2
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
2 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
1 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
2 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 28-31Abstract
Oral delivery of drug is the most preferable route of drug delivery due to ease of administration, patient compliance and flexibility in formulation etc. However, it is a well accepted fact that it is difficult to predict the real in vivo time of release with solid, oral controlled release dosage forms. Various attempts have been made to prolong the retention time of the dosage form in the stomach. One such approach is development of floating Microspheres involves preparation of a device that remains buoyant in the stomach contents due to its lower density than that of the gastric fluids.Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. These microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. Floating microspheres are specially gaining attention due to their wide applicability in the targeting of drugs to stomach.Keywords
Oral Controlled Release Dosage Form, Retention Time, Floating Microsphere.- Method Development and Validation of Ramipril and Amlodipine Besylate by RP-HPLC
Abstract Views :204 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, P.W. College of Pharmacy, Dhamangaon Road, Yavatmal, 445001, IN
1 Department of Quality Assurance, P.W. College of Pharmacy, Dhamangaon Road, Yavatmal, 445001, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1829-1832Abstract
A simple isocratic RP-HPLC method has been developed and subsequently validated for the determination of Ramipril and Amlodipine Besylate in pharmaceutical dosage forms within very short retention time. The method employs an Xterra C18 column, 5 μ, 150 mm x 4.60 mm id with flow rate of 1.5 ml/min using UV detection at 210nm. The separation was carried out using a mobile phase consisting of Sodium Lauryl Sulfate buffer by adjusting pH 2.5 and final composition is Buffer: Acetonitrile: Methanol (45:16.5:38.5)V/V. The retention time for Ramipril and Amlodipine Besylate was found to be 3.1 minutes and 3.8 minutes respectively. The results of analysis were validated statically and by recovery studies. Hence the proposed method was found to be accurate, precise, reproducible and specific and can be used for simultaneous analysis of these drugs in tablet formulation.Keywords
RP-HPLC, Sodium Lauryl Sulfate Buffer, Ramipril, Amlodipine Besylate.- Simultaneous RP-HPLC Determination of Drotaverine Hydrochloride and Mefenamic Acid in their Combined Tablet Dosage Form
Abstract Views :168 |
PDF Views:1
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal-445001 (M.S.), IN
1 P. Wadhwani College of Pharmacy, Yavatmal-445001 (M.S.), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 986-989Abstract
A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure was developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in tablet dosage form at a single wavelength. The mobile phase used was a combination of Methanol:Acetonitrile:KH2PO4 Buffer (10 mM):(40:40:20) pH 3.5. The detection of the combined dosage form was carried out at 240 nm and flow rate was set to 1ml/min. Linearity was obtained in the concentration range of 3 to 30 μg/ml of Drotaverine HCL and 6 to 33 μg/ml of Mefenamic Acid with correlation coefficients of 0.9998 and 0.9999, respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.Keywords
Drotaverine HCL, Mefenamic Acid, RP-HPLC, Simultaneous Estimation.- Application of Simultaneous Equation Method for the Determination of Azithromycin and Cefixime Trihydrate in Tablet formulation
Abstract Views :152 |
PDF Views:4
Authors
Jagdish V. Manwar
1,
Bhagwat U. Nagargoje
2,
Vishal C. Gurumukhi
1,
Dipti G. Ratnaparkhi
1,
Poonam P. Warade
1,
Dipak D. Kumbhar
1,
R. L. Bakal
1,
Rahul S. Manmode
3
Affiliations
1 KYDSCT College of Pharmacy, Sakegaon (Bhusawal) 425 201, Dist. Jalgaon, MS, IN
2 Maharashtra Institute of Pharmacy, MIT Campus, Kothrud, Pune 411038, MS, IN
3 Genzyme Corporation, 500 Soldiers Field Road, Allston 02134, MA, US
1 KYDSCT College of Pharmacy, Sakegaon (Bhusawal) 425 201, Dist. Jalgaon, MS, IN
2 Maharashtra Institute of Pharmacy, MIT Campus, Kothrud, Pune 411038, MS, IN
3 Genzyme Corporation, 500 Soldiers Field Road, Allston 02134, MA, US